Teaching Brief® - MedPage Today
Study Suggests How Two Diabetes Drugs May Exacerbate Heart Failure
ReviewNEW YORK, Sept. 6 -- Experiments in mice suggest that the type 2 diabetes drugs rosiglitazone (Avandia) and pioglitazone (Actos) increase uptake of both glucose and triglycerides in cardiac tissue, causing or exacerbating heart failure.
Primary source: Journal of Clinical InvestigationSource reference: Goldberg IJ et al. "Cardiomyocyte expression of PPARγ leads to cardiac dysfunction in mice." J. Clin. Invest. doi:10.1172/JCI30335.
The study was funded by grants from the Specialized Centers of Clinically Oriented Research and the National Heart, Lung, and Blood Institute. The authors reported that they had no conflicts of interest.
MedPage Today Action Points
Explain to patients who ask that both Avandia and Actos may increase the risk of heart failure and are contraindicated in patients with New York Heart Association stage III or IV heart failure.
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