Monday, November 5, 2007

Electrocardiographic Signs of Remote Myocardial Infarction.

Electrocardiographic Signs of Remote Myocardial Infarction.

Prog Cardiovasc Dis. 2007 November - December;50(3):198-208.

Michael MA, El Masry H, Khan BR, Das MK.

Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN.

Twelve-lead electrocardiogram is an integral part of the evaluation of an acute and a remote myocardial infarction (MI).

Electrocardiographic signs of an acute ST-elevation MI are more precise than those of an acute non-ST-elevation MI.

Recognition of a remote MI is more difficult because once the repolarization abnormalities (ST-segment and T-wave changes) stabilize after an acute MI resolves, then the Q wave remains as the only universally recognized sign of MI.

In addition, there is no specific sign of a non-Q-wave MI or a non-ST-elevation MI, or in fact of an ST-elevation MI that did not result in Q waves.

The fragmented QRS (fQRS) is another recently described sign of a remote MI.
It is defined by the presence of an additional R wave (R') or notching in the nadir of the S wave, or the presence of >1 R' (fragmentation) in 2 contiguous leads corresponding to a major coronary artery territory.

The specificity of fQRS is inferior to that of a Q wave for an MI scar (89% vs 99%). However, fQRS has a superior sensitivity and a negative predictive value compared with a Q wave. In addition, there is an incremental gain in the sensitivity up to 91.4% when these 2 signs (fQRS and Q wave) are combined.

The repolarization abnormalities of MI may also persist indefinitely as a sign of a remote MI in few patients. These abnormalities include persistent ST elevation, ST depression, nonspecific ST-T wave changes, and T-wave inversion.

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