Hotlines and Clinical Trial Updates - Optimal pre-PCI clopidogrel loading: 600mg before every coronary angiography vs. 600 mg in cath-lab only for PCI patients. A randomized multicenter trial: PRAGUE-8.:
Conclusion:
Routine clopidogrel pretreatment before elective coronary angiography is not justified – it increases the risk of bleeding complications, while the benefit on periprocedural infarction is not significant. Clopidogrel should be given only to patients with known coronary angiography who undergo PCI and this can be done safely in the catheterization laboratory between the two procedures.
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