Reductive stress, like its counterpart oxidative stress, can induce cardiomyopathy. August 16th, 2007 - wikidoc

Reductive stress, like its counterpart oxidative stress, can induce cardiomyopathy. August 16th, 2007 - wikidoc

Reductive stress, the counterpart of the more ubiquitous oxidative stress, contributes to cardiomyopathy according to a fascinating new study that for the first time links reductive stress to human disease. Oxidative stress (i.e. excessive production of reactive oxygen species) has clearly been linked to a number of disease states including heart failure. Rajasekaran et al. demonstrate that excessive levels of reducing equivalents (or reductive stress) may underlie the pathogenesis of a specific type of protein aggregation cardiomyopathy caused by mutations in the alphaB-crystallin gene.